Naratriptan hydrochloride( Naratriptan HCl | Amerge | Naramig | GR-85548A )

Catalog No. M18015 CAS No. 143388-64-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Naratriptan hydrochloride
Note

Research use only, not for human use.
Brief Description

Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property.
Description

Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.
In Vitro

——
In Vivo

——
Synonyms

Naratriptan HCl | Amerge | Naramig | GR-85548A
Pathway

Others
Target

Other Targets
Recptor

5-HT1
Research Area

Neurological Disease
Indication

——

CAS Number

143388-64-1
Formula Weight

371.93
Molecular Formula

C17H25N3O2S·HCl
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 35 mg/mL; 94.10 mM
SMILES

CNS(=O)(=O)CCc1cc2c(cc1)[nH]cc2C1CCN(CC1)C.Cl
Chemical Name

N-Methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide hydrochloride

1.Sattar M, Hadgraft J, Lane ME.Int J Pharm. 2015 Sep 30;493(1-2):146-51.

Calculator

molnova catalog